Formerly Covance Antibody Products
Product Index, A-Z
Microtubule Associated Proteins
Spectrin Binding Protein
Myelin Basic Protein
Nuclear Pore Complex 153
Blood Brain Barrier
Tumor Necrosis Factors
Thyroid Stimulating Hormone
Pattern Recognition Receptors
Amyloid Beta C-Terminal mAbs
Amyloid Beta Central mAbs
Amyloid Beta N-Terminal mAbs
Amyloid Beta Peptides
Amyloid Beta Rodent mAbs
Amyloid Beta-Modifiying Protein
HRP USA Detection
Interactive APP Diagram
Terms & Conditions
Nonmuscle Myosin Heavy Chain II-A Polyclonal Antibody, Purified
Myelin Basic Protein (SMI 99) Monoclonal Antibody, Purified
SNAP-25 (SMI 81) Monoclonal Antibody
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IMAGES & PROTOCOLS
BRST-2 (GCDFP-15) Monoclonal Antibody, Purified
Catalog Number SIG-3611
Purified Monoclonal Antibody against BRST-2 (GCDFP-15)
(Formerly Signet Catalog Nos: 611-01, 611-16 L1 Predilute, 611-26 L2 Predilute, 611-36 LV Predilute)
Also Known As
prolactin-inducible protein; secretory actin-binding protein; gross cystic disease fluid protein 15
** In Vitro Diagnostic (IVD) **
Purified Antibody (in PBS with BSA + 0.1%NaN3)
The BRST-2 clone D6 recognizes a 15kDa glycoprotein known as Gross Cystic Disease Fluid Protein-15 (GCDFP-15). The BRST-2 antigen is expressed by apocrine sweat glands, eccrine glands (variable), minor salivary glands, bronchial glands, metaplasmic epithelium of the breast, benign sweat gland tumors of the skin and the serous cells of the submandibular gland. Breast carcinomas (primary and metastatic lesions) with apocrine features express the BRST-2 antigen. This antibody was generated against a gross cystic disease fluid protein 15.
SIG-3611-1000 [1 mL]
SIG-3611-16 [6 mL] is ready to use with Peroxidase Anti-Peroxidase detection systems.
SIG-3611-26 [6 mL] is ready-to-use with Biotin-based detection systems such as USA Ultra Streptavidin Detection (SIG-32250).
SIG-3611-36 [6 mL] is ready-to-use with Biotin based detection systems on Ventana ES and Ventana NexES automated immunostainers.
HE4 Polyclonal Antibody
Cat No. SIG-3731
BRST-1 (CU-18) Monoclonal Antibody
Cat No. SIG-3610
BRST-3 Monoclonal Antibody, Purified
Cat No. SIG-3612
Breast Cancer Resistance Protein (BXP-21) Monoclonal Antibody
Cat No. SIG-38822
Breast Cancer Resistance Protein (BXP-34) Monoclonal Antibody
Cat No. SIG-38820
In Vitro Diagnostic (IVD) use in immunohistochemistry (IHC) test methods only.
This antibody is effective in immunohistochemistry (IHC).
Suggested Working Dilution
The optimal working dilution should be determined for each specific assay condition.
≥1:40 (concentrated format) with Biotin based detection systems such as USA Ultra Streptavidin Detection (SIG-32250).
: Formalin-fixed, paraffin-embedded tissues
: Not required. The BRST-2 epitope is heat-sensitive; paraffin sections that have been heat fixed at 60°C may lose antibody binding sites.
: 20-60 minutes at room temperature
Positive tissue (human): Axilla or breast carcinoma
Store between 2-8
These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website,
). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.
10/08/2014 12:00:00 AM
Fan CY, et al. Expression of androgen receptor and prostatic specific markers in salivary duct carcinoma: an immunohistochemical analysis of 13 cases and review of the literature.
Am J Surg Pathol 24(4)
Wick MR, et al. Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin.
Human Path 20(3)
Haagensen CD. Disease of the breast. 3rd ed., 250-267. W. B. Saunders Co. Philadelphia, PA, 1986.
Mazoujian, G, et al. Extramammary paget’s disease - evidence for an apocrine origin.
Am J. Surg. Pathol. 8(1):
Mazoujian G, et al. Immunohistochemistry of a breast gross cystic disease fluid protein (GCDFP-15): a marker of apocrine epthelium and breast carcinomas with apocrine features.
Am J Pathol 110
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